Manufacturers that have obtained preparation registration can submit a notice to EPA of changing the supplier of the original drug and submit the relevant application form, which does not require approval to change. It is worth noting that the method of use of the original drug registration needs to be consistent with the product of the preparation, while not changing the active ingredient content of the original registered preparation and the limits of related impurities and additives. It should be noted that changes to the source of the original drug can only be submitted via notification if they are exactly as described above.